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20 Pancreatic Polypeptide (PP) Pancreatic polypeptide (PP), a satiety peptide which is structurally similar to PYY, is primarily produced in the pancreas and reduces appetite primarily through signaling in the dorsal vagal complex, particularly the area postrema, which communicates with the hypothalamus

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doi: 10.1073/pnas.91.21.9813

It also plays a key role in the immune system